In an effort to better understand neurological diseases like Alzheimer's, Parkinson's and ALS -- and develop new ways to treat them -- researchers have performed the first meta-analysis of all induced pluripotent stem cell models for neurological and neurodegenerative diseases, and created an atlas of how cell characteristics are linked to their genotype.
A team of scientists has uncovered a surprising molecular link that connects how cells regulate growth with how they sense and make available the nutrients required for growth. The researchers' findings also implicate a new protein, SLC38A9, as a potential drug target in pancreatic cancer.
Scientists have provided new insights into the role of PTEN, a major cancer gene, in controlling cell growth and behavior. PTEN is the second most commonly altered gene in human cancers, particularly prostate cancers, and this work could help to develop and target new treatments.
A metallic probe invented at Rice University that lights up when it binds to a misfolded amyloid beta peptide has identified a binding site that could facilitate better drugs to treat Alzheimer's disease. When the probe is illuminated, it catalyzes oxidation of the protein in a way that might keep it from aggregating in the brains of patients.
Scientists are unlocking the complexities of a recently discovered cell death process that plays a key role in health and disease, and new findings link their discovery to asthma, kidney injury and brain trauma. The results are the early steps toward drug development that could transform emergency and critical care treatment.
Researchers who've analyzed the complete mitochondrial genomes from ancient samples representing two species of saber-toothed cats have a new take on the animals' history over the last 50,000 years. The data suggest that the saber-toothed cats shared a common ancestor with all living cat-like species about 20 million years ago. The two saber-toothed cat species under study diverged from each other about 18 million years ago.
Fruit flies have surprising similarities to humans. The mysteries of a broad range of human conditions can be studied in detail in these organisms, however this often requires the use of expensive custom equipment. team of scientists now present the ethoscope -- a cheap, easy-to-use and self-made customizable piece of equipment of their invention that can be used to study flies' behavior.
Controlling and moving light poses serious challenges. One major hurdle is that light travels at different speeds and in different phases in different components of an integrated circuit. For light to couple between optical components, it needs to be moving at the same momentum. Now, a team of researchers has demonstrated a new way to control the momentum of broadband light in a widely-used optical component known as a whispering gallery microcavity (WGM).
Scientists have completed new simulations that could provide insight into how blobs at the plasma edge behave. The simulations performed kinetic simulations of two different regions of the plasma edge simultaneously.
Flu viruses contain defective genetic material that may activate the immune system in infected patients, and new research published in PLOS Pathogens suggests that lower levels of these molecules could increase flu severity.
An estimated 3 million adult American handgun owners carry a firearm loaded and on their person on a daily basis, and 9 million do so on a monthly basis, new research indicates. The vast majority cited protection as their primary reason for carrying a firearm. It is the first research in more than 20 years to scrutinize why, how often, and in what manner US adults carry loaded handguns.
Environmental disturbances such as El Niño shake up the marine food web off Southern California, new research shows, countering conventional thinking that the hierarchy of who-eats-who in the ocean remains largely constant over time.